Peptides and Biohacking: A Woman’s Guide to Longevity and Health

# Doctor Reviews Peptides – Changing Medicine Forever
# https://www.youtube.com/watch/-AB_qREYFjE

00:00:00.000 I’m a board-certified primary care
00:00:01.760 doctor and I work directly for my
00:00:03.840 patients, which means that I have time
00:00:05.839 to focus on things like actually fixing
00:00:08.320 people versus putting band-aids on
00:00:09.840 things. Improving the way that your body
00:00:11.840 works is something that I’m really on
00:00:13.679 board with. And the more research I do
00:00:15.599 on peptides, the more amazing things I
00:00:18.160 see. Watch this video and you’ll see why
00:00:20.240 peptides aren’t just about muscle gain
00:00:22.240 and fat loss. They’re about repairing
00:00:24.320 the body at its core. And that’s what
00:00:26.160 makes them so powerful. That being said,
00:00:28.640 do not take anything I say on here as
00:00:30.480 medical advice. I’m just a doctor on
00:00:32.320 YouTube talking about research and
00:00:33.840 experimental things here only. I am not
00:00:35.840 your doctor. So, if you don’t already
00:00:37.600 know what peptides are, they are
00:00:39.200 literally chains of amino acids, the
00:00:41.520 same stuff that proteins are made out
00:00:43.040 of. And most of them are designed to fit
00:00:45.120 right into receptors in the body to
00:00:47.280 create some sort of message or signal.
00:00:49.360 Plain and simple, it’s like fitting a
00:00:51.120 key into a lock. They usually come as a
00:00:53.520 white powder like this. And most of the
00:00:56.160 time they’re reconstituted with
00:00:57.680 something like bacteriaatic water and
00:00:59.600 the water mixes with the powder like
00:01:01.120 this. Swirl it around, you’ve got
00:01:03.280 yourself an injectable peptide. Now
00:01:04.959 that’s not actually how it’s done in a
00:01:06.640 sterile environment, but now you know
00:01:08.159 what they look like. You can also think
00:01:09.600 of peptides like text messages between
00:01:11.840 cells. Short, specific, powerful
00:01:14.240 messages. You see, you don’t always need
00:01:15.920 to override your biology with
00:01:17.439 medications. Rather, sometimes you can
00:01:19.520 just send the right signals. signals
00:01:21.680 that teach the body to repair itself, to
00:01:24.320 sleep better, to get stronger or shut
00:01:26.720 down the noise that makes you hungry all
00:01:28.720 the time. And speaking of, there are
00:01:30.400 some peptides that do that. Let me start
00:01:32.000 by describing the most popular weight
00:01:33.840 loss peptides. Semaglutide, tzepide,
00:01:36.640 kagrillinide, and reatride. These
00:01:39.439 peptides basically mimic your own gut
00:01:41.280 hormones. GLP-1, GIP, glucagon, and
00:01:44.720 amalin. They basically talk directly to
00:01:46.880 the brain and the pancreas to restore
00:01:49.759 metabolic rhythms, basically allowing
00:01:51.680 for insulin resistance to die down. And
00:01:53.920 you may have heard me say this before,
00:01:55.520 but I think that insulin resistance is
00:01:58.000 the root of the majority of obesity and
00:02:00.240 disease. Fix insulin resistance, fix
00:02:02.640 obesity, fix a lot of the world’s health
00:02:04.960 problems. And beyond peptides, there are
00:02:07.040 other molecules being researched that
00:02:09.199 work deeper than insulin signaling. Take
00:02:11.440 five amino 1MQ for example which
00:02:13.840 increases NAD and insulin sensitivity by
00:02:17.040 blocking an enzyme that slows down
00:02:18.720 metabolism. I have another video on
00:02:20.640 non-peptides if you want to learn more
00:02:22.160 about that. I mean this is not just
00:02:24.000 appetite suppression with pills. This is
00:02:26.160 a total system reboot. You’re not just
00:02:28.480 muting down a symptom that causes
00:02:30.239 obesity and overeating with peptides.
00:02:32.640 You’re actually rewriting the software
00:02:34.239 that manages appetite and insulin
00:02:36.560 signaling. All right, I’m going to
00:02:37.760 switch gears on you and talk about my
00:02:39.360 favorite thing lately. Mitochondria, the
00:02:41.680 source of energy and endurance. I’m a
00:02:44.319 softy for this stuff because I like to
00:02:46.000 stay active. So energy and endurance are
00:02:47.920 a big deal to me. So your mitochondria,
00:02:49.760 they’re like the batteries in all of
00:02:51.440 your cells. They’re what produces
00:02:53.120 energy. And when they go bad, which they
00:02:55.200 tend to do with aging and inflammation,
00:02:57.760 oxidative stress, everything slows down
00:03:00.319 and you get things like chronic fatigue,
00:03:02.480 inability to sleep, inability to lose
00:03:04.560 weight, all of the above. Okay. But
00:03:06.400 there are two peptides that basically
00:03:08.480 boost your mitochondrial health. You can
00:03:10.319 either get your body to make more
00:03:12.159 mitochondria with MOT C or stabilize the
00:03:15.840 mitochondria that you already have with
00:03:18.000 SS31. SS-31 has been studied in heart
00:03:21.200 failure, kidney disease. It’s even FDA
00:03:23.599 approved for a mitochondrial disease
00:03:25.200 called Bar syndrome. Matsi is a
00:03:27.280 mitochondrial peptide that already
00:03:28.879 exists in our bodies that turns on the
00:03:31.120 signaling that allows you to make more
00:03:32.879 mitochondria and burn more fatty acids.
00:03:35.280 At least that’s what the research in
00:03:36.560 mice shows. These are amazing peptides.
00:03:39.120 And a non-peptide that has less research
00:03:41.680 behind it, but is very promising is SLU
00:03:45.280 PP332, which is basically being called
00:03:48.319 exercise in a bottle. And rightfully so.
00:03:50.799 I have a video comparing all three of
00:03:52.640 those. If you want to learn more, guys,
00:03:54.080 when you combine things like this with
00:03:55.599 things like fasting, cold exposure,
00:03:58.400 exercise, you’re basically signaling
00:04:00.480 your body to create more energy from the
00:04:03.200 inside out to be more efficient, to be
00:04:06.239 better. All right, let’s talk about the
00:04:08.000 peptides that get the most hype about
00:04:10.159 being peptides. Like, when a bro comes
00:04:12.159 to me and says, “Let’s talk about
00:04:13.599 peptides. What can you tell me?” They’re
00:04:15.439 mainly talking about these ones. When it
00:04:17.440 comes to recovery, tissue repair, injury
00:04:20.478 repair, nothing gets more hype than
00:04:22.560 BPC57
00:04:24.160 and TV500. BPC57, it’s a fragment of a
00:04:27.919 peptide that’s made in your stomach
00:04:29.680 naturally that’s thought to protect the
00:04:31.759 lining of the gut due to high cellular
00:04:34.080 turnover in the stomach and the gut. It
00:04:36.800 basically accelerates healing by
00:04:38.479 promoting angioenesis or blood flow and
00:04:41.680 collagen rebuilding. TB500 is found in
00:04:44.960 animal studies in tissues that are
00:04:47.360 trying to repair themselves. Basically,
00:04:49.199 it’s thought to help cells migrate and
00:04:51.759 reorganize after injury. And when you
00:04:53.680 combine them together, it’s like sending
00:04:55.280 a construction crew to an injury.
00:04:57.680 There’s lots of animal research on these
00:04:59.520 two compounds, not a lot of human data,
00:05:01.600 but there are a lot of human stories out
00:05:04.000 there claiming that these compounds have
00:05:06.240 been pretty life-changing. Moving on to
00:05:08.479 body composition. Okay, in the body
00:05:10.320 composition space, these are also very
00:05:12.400 popular peptides that mainly bros in the
00:05:14.639 weightlifting world want to talk about
00:05:16.160 with me. When you hear people talk about
00:05:18.000 CJC1295
00:05:20.000 or seroralin or tessamorin, these are
00:05:23.360 designed to boost natural growth
00:05:25.600 hormone. Boosting growth hormone,
00:05:27.680 especially combined with weight training
00:05:29.840 and good sleep, allows bodies to gain
00:05:32.639 more strength and muscle, burn more fat,
00:05:35.199 and get better sleep and skin quality.
00:05:37.919 What’s the difference between all of
00:05:39.280 these? Basically, CJC 1295 works longer
00:05:42.960 and is a really popular combination with
00:05:45.039 something called Ipamoralin, which I’ll
00:05:46.639 talk about. Suroralin is more short
00:05:48.960 acting and considered a gentler, more
00:05:51.440 physiologic peptide. Tessaoralin also is
00:05:54.479 longer acting, but has incredible fat
00:05:56.960 burning potential. It’s actually FDA
00:05:58.800 approved for something called HIV
00:06:00.400 lipodistrophe. Basically, if somebody
00:06:02.160 with HIV was taking a medication that
00:06:04.400 put fat around their organs, they use
00:06:06.240 tessamorin to burn that fat back off.
00:06:08.880 Ipamoralin, GHRP2, GHRP6,
00:06:13.039 hexelin. These all also boost up growth
00:06:15.600 hormone though through the ghrein
00:06:17.840 pathway. Ghrein is a hormone that makes
00:06:20.000 you hungry. Ipamorin is the most
00:06:22.319 commonly used by people who are
00:06:24.240 basically doing research on their own
00:06:25.680 bodies because it tends to not boost
00:06:28.000 hunger or cortisol as much as the others
00:06:30.319 do. Now physiologically downstream in
00:06:32.720 the hormone pathway of ghrein and growth
00:06:35.199 hormone is IGF-1. And if you want to
00:06:37.520 jump straight to boosting IGF-1 there’s
00:06:39.919 a peptide called IGF LR3 which is a long
00:06:42.880 acting form of IGF-1. And if you want to
00:06:44.960 know the research on just muscular
00:06:46.880 hypertrophy look into something called
00:06:48.479 folstatin. Falstatin basically takes the
00:06:51.120 breaks off of muscular growth. And if
00:06:53.280 you want to look into the fat loss
00:06:54.639 benefits of growth hormone you could
00:06:56.240 look into the research on AOD9604.
00:06:59.120 Okay that was a lot. Let’s take a pause.
00:07:01.440 Okay, good to go. All right, peptides
00:07:03.199 don’t just rebuild muscles. According to
00:07:05.120 the research, they can potentially
00:07:06.720 rebuild neurochemistry and brains.
00:07:08.880 Tesopenine, for example, is a
00:07:10.880 norepinephrine, serotonin, dopamine
00:07:13.599 re-uptake inhibitor that’s been shown in
00:07:16.080 research to reduce appetite while
00:07:18.639 boosting mood and satisfaction. It’s
00:07:21.280 kind of like combining the metabolic
00:07:23.360 effects of the GLP-1, semoglutide,
00:07:25.440 tzepide, reatride with the mental energy
00:07:28.319 of a stimulant like fentamine except it
00:07:31.120 works through your brain’s reward
00:07:33.199 circuitry. There’s also CAX. Research
00:07:35.599 shows that Cax or SAX, I don’t know how
00:07:37.840 you say this one actually. Basically,
00:07:39.440 this is a fragment of act and research
00:07:42.080 shows that it works with BDNF or brain
00:07:44.639 derived neurotrophic factor neur
00:07:47.120 neurotrophic factor and dopamine and
00:07:49.919 serotonin systems contributing to
00:07:52.240 improved memory and focus and selen
00:07:54.879 there’s really great research showing
00:07:56.240 that selen can be used to lessen
00:07:58.479 anxiety. Dhexa is a neutropic peptide
00:08:01.280 that according to research in animals
00:08:03.360 helps form new neural connections. It’s
00:08:06.160 very popular for its ability to
00:08:08.000 potentially improve focus and clarity.
00:08:10.639 It’s also considered a highly promising
00:08:12.800 peptide for cognitive decline. There’s
00:08:15.440 cerebral lycin. This is a blend of
00:08:17.520 peptides that is being researched for
00:08:20.080 recovery from things like stroke and
00:08:22.160 dementia. It’s literally designed to
00:08:24.160 help neurons regrow and reconnect.
00:08:27.280 Imagine medicine helping repair your
00:08:29.680 body’s communication signaling pathways
00:08:32.080 versus just muting things. That’s where
00:08:34.320 we’re headed. All right, let’s talk
00:08:35.599 about skin, hair, and nails. Everybody
00:08:37.360 knows about collagen as a beauty
00:08:38.958 supplement, right? When you digest
00:08:40.880 collagen, you’re actually releasing
00:08:42.719 short peptides that tell your body to
00:08:45.040 make more collagen. It’s basically
00:08:46.880 primitive peptide therapy. GHK copper is
00:08:50.000 a peptide that works with the same idea,
00:08:52.800 just magnified and targeted. It’s a
00:08:55.279 copper binding tripeptide found
00:08:57.440 naturally in your plasma that safely
00:09:00.080 delivers copper to cells which tells
00:09:02.399 them to rebuild and even stimulate new
00:09:05.519 hair follicle growth. Then there’s snap
00:09:07.920 8. This is an octtopeptide that relaxes
00:09:10.959 facial muscle tension by blocking
00:09:13.600 neurotransmitter release. Think of it as
00:09:15.760 like the over-the-counter cousin to
00:09:17.680 Botox. It’s been shown to soften
00:09:19.839 expression lines over time. This is a
00:09:22.000 perfect example of how even cosmetic
00:09:24.240 peptides use the same signaling pathways
00:09:26.640 as therapeutic ones. And these aren’t
00:09:28.560 just cosmetics, they’re cellular
00:09:30.480 tune-ups. Lastly, let’s just talk about
00:09:32.480 some cellular longevity here. Epalen,
00:09:35.519 this is a peptide that supports
00:09:37.360 circadian rhythm and melatonin release,
00:09:40.160 helping you sleep like your younger self
00:09:42.240 used to. According to research, it can
00:09:44.240 actually lengthen tieumirs, basically an
00:09:46.720 anti-aging peptide. KPV as we age
00:09:49.839 basically damaged cells can pile up and
00:09:52.720 cause dysfunction in the body oxidative
00:09:55.120 stress and whatnot and basically the
00:09:56.959 immune system can start to misfire. KPV
00:09:59.680 which is a naturally occurring
00:10:00.959 tripeptide fragment of the hormone alpha
00:10:04.320 MSH helps suppress inflammation at the
00:10:07.680 cellular and gut level. It’s basically
00:10:09.760 being researched to help flip the body
00:10:11.920 back into repair and recovery mode
00:10:13.839 instead of defense mode. Thyosin alpha 1
00:10:16.800 basically strengthens immune
00:10:18.560 coordination. FOX04 DRRI basically helps
00:10:21.839 clear out old damaged cells that are
00:10:24.399 supposed to die off but they don’t. You
00:10:26.240 know that’s not just anti-aging, that’s
00:10:28.160 like cellular housekeeping. So yeah,
00:10:30.320 peptides are popular for helping you get
00:10:32.640 stronger, leaner, smarter, but at their
00:10:35.040 core they basically help your body
00:10:36.880 remember how to heal itself. And that’s
00:10:38.880 the future of medicine. I’m Dr. Ashley
00:10:41.200 Frzy. I run a direct primary care clinic
00:10:43.120 in Mesa, Arizona. It’s basically where I
00:10:45.200 don’t take insurance. My patients just
00:10:46.640 pay me directly. So, we have the freedom
00:10:48.480 to talk about things like this. I
00:10:50.240 appreciate you watching. If you like
00:10:51.600 this video, please hit like for me,
00:10:53.200 subscribe to my channel, and I’ll try to
00:10:54.800 keep making videos that are relevant to
00:10:56.560 you. I hope you have the best day.